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Chen XM, and LaRusso NF. Mechanisms of
attachment and internalization
of Cryptosporidium parvum to biliary and intestinal epithelial cells.
Gastroenterology 2000; 118:368-379.
Chen XM, Levine SA, Splinter
PL, Tietz PS, Ganong AL, Jobin C, Gores GJ, Paya CV, and LaRusso NF.
Cryptosporidium parvum
activates nuclear factor kB in biliary epithelia preventing epithelial cell
apoptosis. Gastroenterology 2001;120:1774-1783.
Chen XM, Keithly JS, Paya CV and LaRusso NF.
Cryptosporidiosis.
New Engl J Med 2002;346(22):1723-1731.
Chen XM and LaRusso NF. Cryptosporidiosis and
the pathogenesis of
AIDS-cholangiopathy. Sem in Liver Dis 2002;22(3):277-289.
Tietz PS, Chen XM, Gong AY,
Huebert RC, Masyuk A, Masyuk T, Splinter PL and LaRusso NF. Experimental models
to study cholangiocyte biology. World J Gastroenterol 2002;8(1):1-4
Gong A-Y, Tietz PS, Muff, MA, Splinter PL,
Huebert RC, Strowski, MZ, Chen, XM, and LaRusso NF. Somatostatin stimulates
ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on
cholangiocytes.
Am J Physiol 2003;284:C1205-C1214.
Tietz P, Marinelli RA, Chen XM, Huang B, Cohn
J, Kole J, McNiven MA, Alper S, and LaRusso NF. Agonist-induced coordinated
trafficking of functionally related transport proteins for water and ions in
cholangiocytes.
J Biol Chem 2003;278:20413-20419.
Chen XM, Huang BQ,
Splinter PL, Cao H, Zhu G, McNiven MA, and
LaRusso NF. Cryptosporidium parvum invasion of biliary epithelia requires
tyrosine phosphorylation of cortactin via c-Src.
Gastroenterology 2003;125(1):216-228.
Chen XM and LaRusso NF.
Cryptosporidium and bile duct injury. Pathophysiology of the Biliary
Epithelia. Alpini G., Alvaro D., LeSage G., and LaRusso NF. eds., Landes
Biosciences and Eurekah.com,
Georgetown, TX 2004; pp357-367.
Huang BQ,
Chen XM, and LaRusso
NF. Mechanisms of attachment and internalization of Cryptosporidium Parvum
by biliary epithelia: a morphologic study. J Parasitol 2004;90(2):212-221.
Chen XM, Huang BQ,
Splinter PL, Orth JD, Daniel D. Billadeau,
McNiven MA, and LaRusso NF. Cdc42 and the
Arp/N-WASP network
mediate cellular invasion of Cryptosporidium parvum.
Infect Immun 2004;72(5):3011-3021.
Chen XM, Splinter PL,
Tietz PS, Billadeau DD and LaRusso NF. Phosphatidylinositol 3-kinase and frabin
mediate Cryptosporidium parvum cellular invasion via activation of
Cdc42.
J Biol Chem 2004;279(30):31671-31678.
Chen XM, O’Hara SP, Huang BQ,
Nelson JB, Zhu G, Ward HD
and
LaRusso NF. Apical organelle discharge by Cryptosporidium parvum is
temperature, cytoskeleton, and intracellular calcium dependent and required
for host cell invasion. Infect Immun 2004;72(12):6806-6816.
O’Hara SP, Huang BQ, Chen XM,
Nelson JB, and LaRusso NF. Distribution of Cryptosporidium parvum
sporozoite apical organelles during attachment to and internalization by
cultured biliary epithelial cells.
J Parasitol 2005;91(5):995-999.
Chen XM, O’Hara SP, Huang BQ, Splinter PL, Nelson JB,
and LaRusso NF. Localized glucose and water influx
facilitates Cryptosporidium parvum
cellular invasion via modulation of host-cell membrane
protrusion.
Proc Nat Acad Sci, USA 2005;102(18):6338-6343.
Chen XM, O’Hara SP,
Nelson JB, Splinter PL, Small AJ, Tietz PS,
Limper AH and LaRusso NF. Multiple Toll-like Receptors are expressed in human
cholangiocytes and mediate host epithelial responses to
Cryptosporidium parvum via activation of NF-kB.
J Immunol 2005;175(11):7447-7456.
Nelson JB, O’Hara SP, Small AJ,
Tietz PS, Choudhury AK, Pagano RE,
Chen XM and LaRusso NF. Cryptosporidium
parvum infects human cholangiocytes via sphingolipid-enriched membrane
microdomains.
Cellular Microbiology 2006;8(12):1932-1945.
Warren S, Chen XM, LaRusso NF and
Badley AD. Apoptosis as a
pathogenic mechanism of HIV-associated opportunistic infection. Cell Death
During HIV Infection. Badley A. ed., Taylor and Francis Publishing,
Boca Raton, FL 2006; 421-440.
Dong HD and Chen XM.
Immunoregulatory role of B7-H1 in chronicity of inflammatory responses. Cell
Mol Immunol 2006;3(3):179-187.
O’Hara SP, Nelson JB, Small AJ,
Badley AD, Chen XM,
Gores GJ and
LaRusso NF. Synergistic effects of HIV-1 Tat protein on
Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent
mechanism. Infect Immun 2007;75(2):684-696.
O’Hara SP, Small AJ, Chen XM and
LaRusso NF. Host cell actin remodeling in response to Cryptosporidium.
Molecular Mechanisms of Parasite Invasion. 2007(in press).
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