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Laurel C. Preheim, M.D
 
Appointment & Titles |  Education |  Research Interests  | Selected Publications |  Contact

Appointment(s) and Titles:
B.S., Bethel College, 1969
M.D., Northwestern University Medical School, 1973

Education:
B.S., Bethel College, 1969
M.D., Northwestern University Medical School, 1973

Research Interests:
Pathogenesis of pneumococcal infection in patients who abuse alcohol. Studies conducted in a rat model of chronic ethanol feeding.

Pathogenesis of pneumococcal infection in patients with cirrhosis. Studies conducted in a rat model of carbon tetrachloride-induced cirrhosis.

Pathogenesis of pneumococcal infections in ethanol abuse.

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Selected Publications:
Preheim LC, Rytel M. Pneumococcal infection after vaccination.(letter) Lancet. 1978;2:1317.

Sanders CC, Sanders WE Jr., Dykstra MA, Preheim L LY 127935 A novel betalactam antibiotic. Current Chemother. Infect. Dis. 1980;1:69-70.

Preheim LC, Sanders WE Jr. Nosocomial pneumonia. Comprehensive Therapy. 1980;7:20-7.

Penn RG, Knoop FC, Giger DK, Preheim LC. Plesiomonas shigeloides overgrowth in the small intestine. J. Clin. Microbiology 1982;15:869-72.

Preheim LC, Penn RG, Sanders CC, Goering RV, Giger DK. Emergence of resistance to beta-lactam and aminoglycoside antibiotic during moxalactam therapy of Pseudomonas aeruginosa infections. Antimicrob. Agents Chemother.

Gotch EL, Baudo JA, Preheim LC. Epidemiology and control of nosocomial infections due to multiply resistant Providencia stuartii. Proceedings of Advanced VA Infection Control Conf. (Salt Lake City, UT) p. 48, September, 1979

Bittner MJ, Dworzack DL, Preheim LC, Tofte RW, Crossley KB. Ceftriaxone treatment of serious bacterial infection in adults.Antimicrob. Agents Chemother. 1983;23:261-6.

Preheim LC, Bittner MJ, Haymond JD. Improving cephalosporin use with education and memoranda reinforcement. In: Spitzy KH, Karrer K, eds. Proceedings of the 13th International Congress of Chemotherapy. Vienna. International Congress of Chemotherapy,1983;73:38-41.

Bittner MJ, Preheim LC, Giger DK, Sanders WE Jr. Mycobacterium fortuitum sternotomy infections: Correlation between susceptibility studies and serum cidal titers during therapy with amikacin, cefoxitin, and rifampin. In: Spitzy KH, Karrer K, eds. Proceedings of the 13th International Congress of Chemotherapy. Vienna. International Congress of Chemotherapy,1983;66:43-6.

Penn RG, Preheim LC, Sanders CC, Giger DK. Comparison of moxalactam and gentamicin in the treatment of complicated urinary tract infections. Antimicrob. Agents Chemother. 1983;24:494-9.



Preheim LC. Lyme disease. Postgraduate Microbiology. 1984; 11:1-3.

O'Donohue WJ, Bedi S, Bittner MJ, Preheim LC. Short- course chemotherapy for pulmonary infection due to Mycobacterium bovis. Arch. Int. Med. 1985;145:703-5.

Delcore MG, Preheim LC. Cellulitis associated with dermatophyte infection in the vein-donor-leg of a coronary artery bypass patient. Nebraska Medical Journal. 1985;70:113-5.

Horowitz EA, Preheim LC, Safranek TJ, Pugsley MP, Sanders CC, Bittner MJ. Randomized, double-blind comparison of ceftazidime and moxalactam in complicated urinary tract infections. Antimicrob. Agents Chemother. 1985;28:299-301.

Preheim LC. Complicated urinary tract infections. Am J Med 1985;79(2A):62-6.

Rabinovitch RA, Koethe SM, Kalbfleisch J, Preheim LC, Rytel MW. Relationship between alternative complement pathway activation, C-reactive protein, and pneumococcal infection. J Clin Microbiol 1986;23:56-61.

Rytel MW, Preheim LC. Antigen detection in the diagnosis and prognostic assessment of bacterial pneumonias. Diagn Microbiol Infect Dis 1986;4:35S-46S.

Brittan JC, Preheim LC. Imported malaria: Problems with diagnosis and prevention. J Fam Pract 1986;22:451-2.

Preheim LC. Poster presenter's thumb. (letter) N Engl J Med 1986;314:1518. Preheim LC, Cuevas TA, Roccaforte JS, Mellencamp MA, Bittner MJ. Ciprofloxacin and antacids. (letter) Lancet. 1986;2:48.

Bittner MJ, Preheim LC, Pugsley MP, Horowitz EA, Strike DG, Sanders CC. Randomized comparison of ceftriaxone andcefamandole therapy of respiratory tract infections in adults. J Antimicrob Chemother 1986;18:621-8.

Preheim LC, Rimland D, Bittner MJ. Methicillin-resistant Staphylococcus aureus in Veterans Administration Medical Centers. Infect Control 1987;8:191-4.

Preheim LC, Cuevas TA, Roccaforte JS, Mellencamp MA, Bittner MJ. Oral ciprofloxacin for complicated urinary tract infections due to trimethoprim/sulfamethoxazole-resistant bacteria in elderly patients. Am J Med 1987;82(4A):295-300.

Gilbert DN, Tice AD, Marsh PK, Craven PC, Preheim LC. Oral ciprofloxacin therapy of chronic contiguous osteomyelitis due to aerobic gram-negative bacilli. Am J Med 1987;82(4A):254-8.

Mellencamp MA, Preheim LC, McDonald TL. Isolation and characterization of circulating immune complexes from patients with pneumococcal pneumonia. Infect Immun 1987;55:1737-42.



Horowitz EA, Preheim LC, Safranek TJ, Pugsley MP, Sanders CC, Bittner MJ. Randomized, double-blind comparison of ceftazidime and moxalactam in complicated urinary tract infections. In: SM Wolff, FP Tally, GT Keusch, MS Klempner, DR Snydman (eds.) The Year Book of Infectious Diseases. Chicago, Year Book Medical Publishers, 1987, pp. 49-50.

Preheim LC, Rimland D, Bittner MJ. Methicillin-resistant Staphylococcus aureus in Veterans Administration Medical Centers. In: DE Rogers, RM Des Prez, MJ Cline, E Braunwald, NJ Greenberger, JD Wilson, FH Epstein, and SE Malawista (eds.). Year Book of Medicine. Chicago, Year Book Medical Publishers, 1988, pp. 51-4.

Roccaforte JS, Bittner MJ, Stumpf C, Preheim LC. Attempts to eradicate colonization with methicillin- resistant Staphylococcus aureus using trimethoprim-sulfamethoxazole, rifampin, and bacitracin. Am J Infect Control 1988;16:141-6.

Allais JM, Preheim LC, Cuevas TA, Roccaforte JS, Mellencamp MA, Bittner MJ. Randomized, double-blind comparison of ciprofloxacin and trimethoprim/sulfamethoxazole in complicated urinary tract infections. Antimicrob Agents Chemother 1988;32:1327-30.

Mellencamp MA, Roccaforte JS, Preheim LC, Sanders CC, Anene CA, Bittner MJ. Susceptibility of Enterobacter aerogenes to $-lactam antibiotics despite high level $-lactamase production. Eur J Clin Microbiol Infect Dis 1990;9:827-30.

Effects of cirrhosis on pulmonary defense mechanisms against Streptococcus pneumoniae. J Infect Dis 1991;163:102-8.

Preheim LC. Poster presenter's thumb. In: Bennett HJ The Best of Medical Humor. A collection ofarticles, essays, poetry, and letters published in
the medical literature. Philadelphia, Hanley and Belfus, Inc.,1991, p. 110. Sookpranee T, Sookpranee M, Mellencamp MA, Preheim LC. Pseudomonas pseudomallei: A common pathogen in Thailand that is resistant to the bactericidal effects of many antibiotics. Antimicrob Agents Chemother 1991;35:484-9.

Davis CC, Mellencamp MA, Preheim LC. A model ofpneumococcal pneumonia in chronically intoxicated rats. J Infect Dis 1991;163:799-805. Snitily MU, Gentry MJ, Mellencamp MA, Preheim LC. A simple method for collection of blood from the rat foot. Lab Animal Sci 1991; 41:285-7.

Preheim L, Pitcher D, Owen R, Cookson B. Typing of methicillin-resistant and susceptible Staphylococcus aureus strains by ribosomal RNA gene restriction patterns using a biotinylated probe. Eur J Clin Microbiol Infect Dis 1991;10:428-36.

Auten GM, Preheim LC, Sookpranee M, Bittner MJ, Sookpranee T, Vibhagool A. High pressure liquid chromatography and microbiological assay of serum ofloxacin levels in adults receiving intravenous and oral therapy for skin infections. Antimicrob Agents Chemother 1991;35:2558-61.

Preheim LC, Gentry MJ, Snitily MU. Pulmonary recruitment, adherence, and chemotaxis of neutrophils in a rat model of cirrhosis and pneumococcal pneumonia. J Infect Dis 1991;164:1203-6.



Lentino JR, Preheim LC, Mellencamp MA, Dworzack DL. Oral ciprofloxacin versus parenteral ceftriaxone therapy of osteomyelitis due to Staphylococcus aureus and other pathogens. In: Rubinstein E, ed. Proceedings of the 3rd International Symposium on New Quinolones. Vancouver. Eur J Clin Microbiol Infect Dis, 1991, pp. 411-2.

Preheim LC, Auten GM, Sookpranee M, Bittner MJ, Sookpranee T, Vibhagool A. Safety and efficacy of ofloxacin therapy for skin and soft tissue infections in hospitalized adults. In: Rubinstein E, ed. Proceedings of the 3rd International Symposium on New Quinolones. Vancouver. Eur J Clin Microbiol Infect Dis, 1991, pp. 323-4.

Preheim LC. Infectious complications of alcoholism. Infect Dis Pract, 1992;16:1-7.

Horowitz EH, Preheim LC, Neumann TV, Bittner MJ. Hepatotoxicity due to amphotericin B. Infect Dis Clin Pract 1992;1:123-5.

Lister PD, Mellencamp MA, Preheim LC. Serum-sensitive Escherichia coli multiply in cirrhotic serum. J Lab Clin Med 1992;120:-633-8.

Preheim LC, Mellencamp MA, Snitily MU, Gentry MJ. Effect of cirrhosis on the production and efficacy of pneumococcal capsular antibody in a rat model. Am Rev Respir Dis, 1992;146:1054-8.

Preheim LC. Pulmonary infiltrates in cancer patients. Infect Dis Pract 1993;17:1-5.

Boken DJ, Leoni PA, Preheim LC. Treatment of Strongyloides stercoralis hyperinfection syndrome with thiabendazole administered per rectum. Clin Infect Dis 1993;16:123-6.

Lister PD, Gentry MJ, Preheim LC. Ethanol impairs neutrophil chemotaxis in vitro but not adherence or recruitment to lungs in rats with experimental pneumococcal pneumonia. J Infect Dis 1993;167:1131-7.

Lister PD, Gentry MJ, Preheim LC. Granulocyte colony-stimulating factor protects control rats but not ethanol-fed rats from fatal pneumococcal pneumonia. J Infect Dis 1993;168:922-6.

Boken DJ, Preheim LC. Urinary tract infection. Short course therapy. Infect Dis Pract 1994;18:57-60.

Gentry MJ, Snitily MU, Preheim LC. Phagocytosis of Streptococcus pneumoniae measured in vitro and in vivo in a rat model of carbon tetrachloride-induced liver cirrhosis J Infect Dis 1995;171:350-5.

Hanson MN, Preheim LC, Chou S, Talarico CL, Biron KK, Erice A. Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to gancyclovir. Antimicrob Agents Chemother 1995;39: 1204-5.

Preheim LC, Childs SJ, Rajfer J, Bittner MJ. Randomized, double-blind comparison of cefepime and ceftazidime therapy for urinary tract infection. Curr Ther Res 1995; 56:729-37.

Jareo P, Preheim LC, Lister PD, Gentry MJ. The effect of ethanol ingestion on killing of Streptococcus pneumoniae, Staphylococcus aureus, and Staphylococcus epidermidis by rat neutrophils. Alcohol Alcoholism 1995; 30:311-18.

Bittner MJ, Horowitz EA, Safranek TJ, Preheim LC. Emergence of Mycobacterium kansasii as the leading mycobacterial pathogen over a 20-year period at a midwest Veterans Hospital with declining Mycobacterium tuberculosis. Clin Infect Dis 1996;22:1109-10.



Gentry MJ, Snitily MU, Preheim LC. Decreased uptake and killing of Streptococcus pneumoniae within the lungs of cirrhotic rats. Immunol Infect Dis 1996;6:43-7.

Preheim LC, Snitily MU, Gentry MJ. Effects of granulocyte colony-stimulating factor in cirrhotic rats with pneumococcal pneumonia. J Infect Dis 1996;174:225-8.

Jareo PW, Preheim LC, Gentry MJ. Ethanol ingestion impairs neutrophil bactericidal mechanisms against Streptococcus pneumoniae. Alcoholism Clin Exp Res 1996;20:1646-52.

Smith TL, Preheim LC. Scrofula: The king's touch revisited. Infect Dis Practice 1997;21:1-3.

Barry JW, Dominguez EA, Boken DJ, Preheim LC. Hafnia alvei infections after liver transplantation. Clin Infect Dis 1997;24:1263-4.

Jareo PW, Preheim LC, Snitily MU, Gentry MJ. Isolation of peripheral blood neutrophils from rats using magnetic cell sorting. Lab Animal Sci 1997;47:414-418.

Preheim LC, Smith TL. Mycobacterial infections. New threats from old disease. Comprehensive Therapy 1997;23:310-18.

Henriksen JL, Preheim LC, Gentry MJ. Vaccination with protein-conjugated and native type 3 capsular polysaccharide in an ethanol-fed rat model of
pneumococcal pneumonia. Alcoholism Clin Exp Res 1997;21:1630-7.

Preheim LC. Career opportunities for infectious diseases subspecialists. Clin Infect Dis 1998;26:277-281.

Joiner KA, Powderly WG, Blaser MJ, Klempner MS, Locksley RM, Mandell GL, Preheim LC, Remington JS, Slama TG, Steigbigel NH, Bartlett JG. Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors. Clin Infect Dis 1998;26:1060-5.

Ellbogen MH, Preheim LC. Lemierre's syndrome: features of a classic infectious disease. Infect Dis Practice 1999;23:1-3.

Preheim LC, Olsen KM, Yue M, Snitily MU, Gentry MJ. Ethanol feeding does not affect the efficacy or pharmacokinetics of azithromycin, trovafloxacin, or ceftriaxone in a rat model of pneumococcal pneumonia. Alcoholism Clin Exp Res 1999;23:842-849.

Alcantara RB, Preheim LC, Gentry MJ. The role of pneumolysin's complement-activating activity during pnuemococcal bacteremia in cirrhotic rats. Infect Immun 1999;67:2862-2866.

McCashland TM, Gentry MJ, Preheim LC. Effects of cirrhosis and liver transplantation on response to pneumococcal vaccine. (submitted, J Infect Dis).